Inter vs Sassuolo Preview, Prediction, Head-to-Head, Team News, Possible Line-ups, and Betting Tips

Peter Solomon

Peter Solomon is a sports writer and a Manchester United fan who delivers insights and stories behind the scores. He is also a professional sports betting analyst, offering expert perspectives on odds, strategies, and the business side of the game.

3 Minutes Read
September 14, 2025

The Serie A leaders, Inter Milan, return to the fortress of the Stadio Giuseppe Meazza to host a struggling Sassuolo side. Inter, fresh from clinching the Scudetto and in imperious form, will be looking to continue their celebratory march. Sassuolo, embroiled in a fierce relegation battle, are desperate for points but face the league’s most daunting task. This home vs away match preview pits the best against a team fighting for survival.

Inter vs Sassuolo Match Preview/Betting Preview

This home vs away betting preview is a classic case of a top-team versus a bottom-team dynamic. Inter, even with potential rotations, will look to dominate possession, press high, and overwhelm Sassuolo with their attacking quality. Sassuolo’s fragile defence will be tasked with containing the league’s best attack. The key question for this betting preview is not if Inter will win, but by how many, and whether Sassuolo can muster any kind of response.

Team Recent Form

Inter: WWWWW

Sassuolo: LLLDL

Key Stats

Inter have won their last 10 matches across all competitions.
Sassuolo have the worst defensive record in Serie A this season.
Inter have scored at least two goals in each of their last nine league games.

I predict the correct score will be Inter 4 – 0 Sassuolo. The gulf in class, form, and confidence is astronomical. Even with a rotated squad, Inter’s strength in depth is superior to Sassuolo’s best XI. Expect a dominant, one-sided performance from the champions, who will likely score early and cruise to a comprehensive victory against a demoralized opponent.

Inter vs Sassuolo H2H

Inter have won the last three head-to-head meetings.
The reverse fixture ended in a 2-1 victory for Inter at the Mapei Stadium.
Sassuolo’s last win against Inter was a 2-1 victory in February 2023.
Matches between these two are typically high-scoring, with Over 2.5 goals landing in four of the last five encounters.

Pre Game Odds

Inter Win: 1/6
Draw: 6/1
Sassuolo Win: 14/1

(Odds are indicative and subject to change)

Team News Home

With the title secured, Inter manager Simone Inzaghi is expected to rotate his squad heavily. Key players like Lautaro Martínez and Nicolò Barella may be rested or start on the bench. This provides opportunities for players like Marko Arnautović and Alexis Sánchez.

Team News Away

Sassuolo have a lengthy injury list, missing key defenders and midfielders. Their top scorer, Domenico Berardi, remains a long-term absentee. The team’s morale is at a low ebb following a string of heavy defeats.