Napoli vs SC Pisa preview, prediction, head-to-head, team news, possible line-ups, and betting tips

Adesoji Michael

Adesoji Michael is a professional sports journalist and betting expert, delivering insightful analysis, match previews, and data-driven predictions. With a strong grasp of betting markets and storytelling, I help readers make informed decisions while enjoying the thrill of sports. Connect with me on socials for more insightful content.

4 Minutes Read
September 20, 2025

A classic Coppa Italia showdown is on the cards at the iconic Stadio Diego Armando Maradona as Serie A giants Napoli play host to recently promoted outfit SC Pisa. For the home side, this is the start of their journey in a competition they will have serious ambitions of winning, and it represents a fixture they are overwhelmingly expected to navigate with ease. For the visitors from Tuscany, this is a glamour tie – a free hit and a fantastic opportunity to test their mettle against some of the best players in the country on one of Italian football’s grandest stages.

This Napoli vs SC Pisa preview will break down the considerable gulf in class between the two sides, analyse their respective league form, and look at the likely team news, with a special focus on squad rotation. We will provide expert betting tips for a cup match that pits a national powerhouse against a hopeful underdog.

Napoli vs SC Pisa Match Preview/Betting Preview

Team Recent Form

The two clubs enter this cup tie with strong form in their respective divisions, but the quality of opposition has been vastly different.

Napoli: WWDWW
SC Pisa: DWLWD

Key Stats

Napoli have won 12 of their last 13 home matches in the Coppa Italia against teams from a lower division.
SC Pisa have lost their last five Coppa Italia matches against Serie A opposition, failing to score in four of them.
These two sides have not met in a competitive fixture in over 30 years, highlighting the different paths the clubs have been on.

My prediction is a comfortable 3-0 win for Napoli. While cup competitions can always spring a surprise, the chasm in quality between these two squads is simply too vast to ignore. Even with the wholesale changes expected from manager Antonio Conte, Napoli’s second-string lineup is filled with seasoned international players who will be far too strong for Pisa’s first team. Expect Napoli to control the game from the outset and secure a professional, comprehensive victory to advance to the next round.

Napoli vs SC Pisa H2H

There is no modern head-to-head record to analyse, which in itself tells the story of the gulf between the teams.

This will be the first competitive meeting between Napoli and SC Pisa in the 21st century.
The last encounters took place in Serie B during the 1993-94 season.
Napoli are unbeaten in their last 15 Coppa Italia home games against lower-league opposition.
Pisa have been eliminated from the Coppa Italia by Serie A teams in four of their last five campaigns.

Pre-Game Odds

Napoli Win: 1.15
Draw: 8.00
SC Pisa Win: 15.00

(Odds are subject to change and may vary between bookmakers)

Team News Napoli

The key news for Napoli is the certainty of heavy squad rotation. Manager Antonio Conte will use this fixture to rest his star players ahead of crucial league and European matches. Expect key figures like Khvicha Kvaratskhelia, Victor Osimhen, and Stanislav Lobotka to be given the night off. This provides a crucial opportunity for fringe players like Giovanni Simeone, Jesper Lindstrøm, and Jens Cajuste to stake their claim for more minutes.

Team News SC Pisa

In stark contrast to their hosts, SC Pisa will arrive in Naples with their strongest possible lineup. Manager Filippo Inzaghi has a fully fit squad to choose from and will see this as a ‘cup final’ for his players. There will be no rotation as the Serie B side looks to pull off one of the biggest upsets in the club’s recent history.