Manchester United host AS Roma at Old Trafford on Tuesday night in the UEFA Champions League, with the hosts in desperate need of a response after four defeats in five games. Roma, by contrast, are unbeaten in Serie A this season and arrive on the back of a 5-2 win at Udinese, but they are without their first-choice goalkeeper and probably without Paulo Dybala.
This Manchester United vs AS Roma prediction is a fascinating one for bettors because the form gap points one way and the fixture history points the other: United have won all four home meetings against Roma in Europe.
Manchester United vs AS Roma Match Preview
United’s recent run has been bleak: a 2-0 defeat at Chelsea, a 3-0 home defeat to Bournemouth, a 4-1 defeat at Como in Europe and a 2-0 defeat at Atlético Madrid, with only a 1-1 draw at Leeds breaking the sequence. Roma’s run has been the opposite: 5-2 at Udinese, 4-2 against Cagliari, 3-3 at Napoli, 4-0 against Slovan Bratislava in Europe and 2-0 against Genoa.
Team Recent Form
Manchester United (most recent first): L-L-L-D-L — Chelsea 2-0 Manchester United (Premier League); Manchester United 0-3 Bournemouth (Premier League); Como 4-1 Manchester United (Champions League); Leeds United 1-1 Manchester United (Premier League); Atlético Madrid 2-0 Manchester United (Champions League).
AS Roma (most recent first): W-W-D-W-W — Udinese 2-5 Roma (Serie A); Roma 4-2 Cagliari (Serie A); Napoli 3-3 Roma (Serie A); Roma 4-0 Slovan Bratislava (Champions League); Roma 2-0 Genoa (Serie A).
Key Stats
- Manchester United have scored just two goals in their last five games in all competitions and have conceded 12 in that run.
- Roma are unbeaten in Serie A this season, with seven wins and three draws from ten games, and have scored 28 goals in those ten games.
- Manchester United have won all four home meetings against Roma in Europe.
1-2 is our correct-score prediction: Roma’s attacking form should be too much for a United defence that has conceded nine goals in its last three games, but United’s home record in this fixture means they should score at least once.
Manchester United vs AS Roma H2H
- 6 May 2021: Roma 3-2 Manchester United (Europa League semi-final, 2nd leg)
- 29 April 2021: Manchester United 6-2 Roma (Europa League semi-final, 1st leg)
- 9 April 2008: Manchester United 1-0 Roma (Champions League quarter-final, 2nd leg)
- 1 April 2008: Roma 0-2 Manchester United (Champions League quarter-final, 1st leg)
Pre Game Odds
- Manchester United win: 2.44
- Draw: 4.06
- AS Roma win: 2.78
Odds via Mightytips (1 Nov 2026), pre-match and subject to change.
Team News Manchester United
Manchester United are without Benjamin Šeško (shin injury, out for the remainder of 2026), Luke Shaw, Patrick Dorgu and Manuel Ugarte. Amad Diallo is a doubt after coming off against Chelsea, and Marcus Rashford is not confirmed for the squad. Lisandro Martínez was sent off against Chelsea in the Premier League but remains eligible in the Champions League, while Bruno Fernandes returned against Chelsea and Kobbie Mainoo could start.
Predicted Manchester United XI (predicted only, not confirmed): Lammens; Mazraoui, Maguire, De Ligt, Dalot; Tielemans, Baleba; Amad, Fernandes, Cunha; Mbeumo.
Team News AS Roma
Roma are without Lorenzo Pellegrini (thigh injury, missed the last three games), Paulo Dybala (calf injury, missed the last five, though one preview reports him back in training, so he is treated as doubtful rather than confirmed available) and first-choice goalkeeper Mile Svilar (protective boot, return unlikely before the international break). Manu Koné (muscle issue) is the only absentee who could return on Tuesday, while Donyell Malen scored at Udinese and is expected to lead the attack.
Predicted AS Roma XI (predicted only, not confirmed): Gollini; Mancini, Balerdi, Hermoso; Molina, De Roon, Mora, Cristante, Wesley; Soulé, Malen.
Manchester United vs AS Roma Betting Tips
Tip 1 – Result: AS Roma win. Tip 2 – Over-Under 2.5: Over 2.5 goals. Tip 3 – BTTS Yes-No: Both teams to score – Yes.
Roma’s form gap over United is too large to ignore, even with their absentees — but United’s perfect home record against Roma in Europe means this should be a competitive game, not a procession.
See more previews in the Matches archive for this Manchester United vs AS Roma prediction, and follow the UEFA Champions League via UEFA for official fixture news.
Manchester United vs AS Roma prediction
This Manchester United vs AS Roma prediction points to an AS Roma win, with 1-2 as the correct-score call in this Manchester United vs AS Roma prediction.
In short, this Manchester United vs AS Roma prediction backs Roma, and this Manchester United vs AS Roma prediction will be settled at Old Trafford on Tuesday night.
That is why this Manchester United vs AS Roma prediction, like the earlier Manchester United vs AS Roma prediction above, keeps Roma as the pick for Tuesday night.
