Sevilla's attack should settle this early against a lower-league side, and an early goal kills the tie before the home crowd can lift Hortaleza.

Athletic Bilbao are the clear favourites against a lower-league side, and the most likely scoreline is Athletic 0-2.

Getafe have yet to score away in the league this season and Lebrijana kept it tight through the preliminary round, so a low-scoring away win is the likeliest shape.

Osasuna are the LaLiga side in this single-leg tie, and a clean sheet is a plausible outcome against lower-tier opposition at the Estadio Municipal de San Inigo.