Napoli vs Pisa Preview, Prediction, Head-to-Head, Team News, Possible Line-ups, and Betting Tips

Peter Solomon

Peter Solomon is a sports writer and a Manchester United fan who delivers insights and stories behind the scores. He is also a professional sports betting analyst, offering expert perspectives on odds, strategies, and the business side of the game.

3 Minutes Read
September 14, 2025

The Stadio Diego Armando Maradona hosts a Coppa Italia clash as Napoli from Serie A take on Pisa from Serie B. The reigning Italian champions are heavy favorites, but will be wary of a cup upset against a disciplined Pisa side that is pushing for promotion. This home vs away match preview examines whether the Partenopei’s individual quality can overcome a potential tactical challenge from the lower-league visitors.

Napoli vs Pisa Match Preview/Betting Preview

This home vs away betting preview hinges on Napoli’s ability to break down a well-organized defence. Pisa will likely employ a low defensive block, look to frustrate Napoli, and seek opportunities from set-pieces or counter-attacks. Napoli will control possession and rely on the creative talents of players like Khvicha Kvaratskhelia to unlock a stubborn backline. The key betting question is whether Napoli can translate their dominance into a comfortable victory or if Pisa can keep it close.

Team Recent Form

Napoli: LWWLD

Pisa: DWWLW

Key Stats

Napoli have won the Coppa Italia six times, most recently in 2020.
Pisa are currently in the Serie B playoff places and are in strong form.
This is the first meeting between these two clubs since the 2014-15 season.

I predict the correct score will be Napoli 2 – 0 Pisa. While Pisa will be organized and difficult to break down initially, the sheer gulf in individual talent should eventually prevail. Napoli’s superior quality in the final third will likely see them score in each half, with Pisa offering limited threat in attack against a top-flight defence.

Napoli vs Pisa H2H

The teams have not met in over a decade.
Their last encounter was in Serie B during the 2014-15 season, a 1-1 draw.
Napoli are unbeaten in their last four matches against Pisa (W2 D2).
Pisa’s last victory over Napoli was a 1-0 win in a Coppa Italia match in 1987.

Pre Game Odds

Napoli Win: 2/9
Draw: 5/1
Pisa Win: 12/1

(Odds are indicative and subject to change)

Team News Home

Napoli manager Francesco Calzona is expected to rotate his squad. Key striker Victor Osimhen is a major doubt and is likely to be rested. This could see Giovanni Simeone lead the attack. Midfielder Stanislav Lobotka may also be given a break.

Team News Away

Pisa will be without their first-choice goalkeeper due to suspension. They have no other significant injury concerns and are expected to field a full-strength, defensive lineup in the hope of causing an upset.